Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats.

@article{Zhang2014EffectsOC,
  title={Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats.},
  author={Lin Zhang and Junxia Luo and Minghua Zhang and Wei Yao and Xuelian Ma and Shu-Yan Yu},
  journal={The international journal of neuropsychopharmacology},
  year={2014},
  volume={17 5},
  pages={793-806}
}
Depression is a neuropsychiatric disease associated with wide ranging disruptions in neuronal plasticity throughout the brain. Curcumin, a natural polyphenolic compound of curcuma loga, has been demonstrated to be effective in the treatment of depressive-like disorders. The present study aimed to investigate the mechanisms underlying the antidepressant-like effects of curcumin in a rat model of chronic, unpredictable, mild, stress (CUMS) -induced depression. The results showed that CUMS… CONTINUE READING