Effects of crystalline state and self-nanoemulsifying drug delivery system (SNEDDS) on oral bioavailability of the novel anti-HIV compound 6-benzyl-1-benzyloxymethyl-5-iodouracil in rats

@article{Lu2018EffectsOC,
  title={Effects of crystalline state and self-nanoemulsifying drug delivery system (SNEDDS) on oral bioavailability of the novel anti-HIV compound 6-benzyl-1-benzyloxymethyl-5-iodouracil in rats},
  author={Y. Lu and Wenbing Dai and X. Wang and Jun-Yi Liu and P. Li and Y. Lou and Chuang Lu and Q. Zhang and G. Zhang},
  journal={Drug Development and Industrial Pharmacy},
  year={2018},
  volume={44},
  pages={329 - 337}
}
Abstract The objective of this study was to investigate the effect of crystalline state and a formulation of self-nanoemulsifying drug delivery system (SNEDDS) on oral bioavailability of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor, in rats. The crystalline states of W-1 were characterized by scanning electron microscope (SEM), differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD). The SNEDDS was formulated by medium… Expand
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2 Citations

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