Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia

@article{Zheng2007EffectsOC,
  title={Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia},
  author={Yong-qiu Zheng and Jian-xun Liu and Jan-Nong Wang and Li Xu},
  journal={Brain Research},
  year={2007},
  volume={1138},
  pages={86-94}
}
This paper studied the effects of crocin, a pharmacologically active component of Crocus sativus L., on ischemia/reperfusion (I/R) injury in mice cerebral microvessels. Transient global cerebral ischemia (20 min), followed by 24 h of reperfusion, significantly promoted the generation of nitric oxide (NO) and malondialdehyde (MDA) in cortical microvascular homogenates, as well as markedly reduced the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) and promoted the… Expand
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Results suggested that the neuroprotective effects of shikonin against cerebral ischemia/reperfusion injury may be attributed to its antioxidant effects. Expand
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TLDR
Saffron has protective effects against oxidative ischemic damage and brain edema in a transient model of focal cerebral ischemia in rats, probably induced by increasing the capacity of antioxidant enzymes and decreasing the production of free radicals. Expand
Crocin protects against cerebral- ischemia-induced damage in aged rats through maintaining the integrity of blood-brain barrier.
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Findings indicate that crocin or related antioxidants may protect against cerebral ischemia of elderly patients by maintaining the integrity of BBB in aged rats, an effect likely through repressing the activation of matrix metalloproteinase pathway. Expand
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TLDR
The findings indicated that crocin effectively reduces brain ischemia-induced injury and improves neurological outcomes and Crocin also is a potent neuroprotective factor that can be able to prevent histopathological alterations following brain isChemia. Expand
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References

SHOWING 1-10 OF 64 REFERENCES
Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia.
TLDR
The hypothesis that in addition to the detrimental action of NO formed by neuronal NOS during ischemia, NO generation at reperfusion plays a significant role in reperfusions injury, possibly through peroxynitrite formation is supported. Expand
Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: Effects of the PPAR-α agonist WY14643
This study investigated the effects of the selective peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist WY14643 on ischemia/reperfusion (I/R) injury in the rat hippocampus.Expand
Reperfusion-Induced Oxidative/Nitrative Injury to Neurovascular Unit After Focal Cerebral Ischemia
TLDR
During reperfusion, intense superoxide, NO, and peroxynitrite formation on microvessels and surrounding end-feet may lead to cerebral hemorrhage and edema by disrupting microvascular integrity. Expand
Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus.
  • H. Hosseinzadeh, H. Sadeghnia
  • Chemistry, Medicine
  • Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2005
TLDR
It is concluded that safranal have some protective effects on different markers of oxidative damage in hippocampal tissue from ischemic rats. Expand
Significance of xanthine oxidase in the production of intracellular oxygen radicals in an in-vitro hypoxia-reoxygenation model.
TLDR
The results support the pivotal role of intracellular ROS generated by xanthine oxidase in reoxygenated cell injury, and suggest the viability of using an intrACEllular antioxidative therapy for reperfusion injury of the liver. Expand
Effect of Saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats.
TLDR
The present results may suggest the effectiveness of CS in focal ischemia most probably by virtue of its antioxidant property. Expand
Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice: Implications for the Production and Role of Superoxide Radicals
TLDR
It is suggested that mitochondrial O2·− production may be a critical step underlying the mechanism of ischemia/reperfusion injury and that MnSOD may protect against ongoing oxidative cell death after ischemIA/rePerfusion. Expand
Cerebroprotective effect of Korean ginseng tea against global and focal models of ischemia in rats.
TLDR
The protective action, exhibited by KGT against hypoperfusion/reperfusion induced brain injury, suggests its therapeutic potential in cerebrovascular diseases (CVD) including stroke. Expand
Nitric oxide mediates hypoxia-induced changes in paracellular permeability of cerebral microvasculature.
TLDR
Results from this study suggest that hypoxia-induced blood-brain barrier breakdown can be diminished by inhibition of NO synthesis, decreased concentration of NO metabolites, and/or reoxygenation. Expand
Oxygen radicals in cerebral ischemia: the 2001 Willis lecture.
TLDR
The inhibition of AMPA receptors may be a promising approach to inhibit the production of oxygen radicals during ischemia-reperfusion of the brain. Expand
...
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3
4
5
...