Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation

@article{Watanabe2002EffectsOC,
  title={Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation},
  author={Airi Watanabe and Nobumasa Kato and Tadafumi Kato},
  journal={Neuroscience Research},
  year={2002},
  volume={42},
  pages={279-285}
}

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References

SHOWING 1-10 OF 32 REFERENCES
Central and peripheral factors in fatigue
TLDR
The data support the exciting possibility that relationships exist among nutrition, brain neurochemistry and sport performance, and while the evidence is intriguing and makes good intuitive sense, knowledge in this area is rudimentary at best.
Physical and mental fatigue: metabolic mechanisms and importance of plasma amino acids.
There are at least 5 metabolic causes of fatigue, a decrease in the phosphocreatine level in muscle, proton accumulation in muscle, depletion of the glycogen store in muscle, hypoglycaemia and an
Relationship of Energy Metabolism Detected by 31P-MRS in the Human Brain with Mental Fatigue
TLDR
Findings suggest that characteristics of brain energy metabolism in an individual may relate to intrinsic patterns of mental fatigability.
Creatine enhances oxygen uptake and performance during alternating intensity exercise.
TLDR
The results indicate that Cr feeding increases the capacity of human muscle to perform work during alternating intensity contraction, possibly as a consequence of increased aerobic phosphorylation and flux through the creatine kinase system.
Clinical pharmacology of the dietary supplement creatine monohydrate.
TLDR
This review covers the basics of creatine synthesis and transport, proposed mechanisms of action, pharmacokinetics of exogenous creatine administration, creatine use in disease models, side effects associated with use, and issues on product quality.
Creatine supplementation in health and disease: What is the evidence for long-term efficacy?
TLDR
The primary purpose of the present review article is to critically evaluate the available evidence for long-term efficacy of creatine administration and to hypothesize about ways to optimize creatine administration regimens.
Effect of oral creatine supplementation on respiratory gas exchange and blood lactate accumulation during steady-state incremental treadmill exercise and recovery in man.
TLDR
The results showed no measurable effect of creatine supplementation on respiratory gas exchange and blood lactate concentrations during either incremental submaximal exercise or recovery, which suggests that creatine supplementation does not influence substrate utilization during and after this type of exercise.
Alteration of hemoglobin oxygenation in the frontal region in elderly depressed patients as measured by near-infrared spectroscopy.
TLDR
Results suggest that functional hypofrontality in elderly depression is not due to altered vasodilator response, and alterations of oxyhemoglobin and deoxyhemoglobin were examined by using near-infrared spectroscopy of the left frontal region.
Lactate efflux and the neuroenergetic basis of brain function
TLDR
A stoichiometric relation between OGI and lactate concentration is derived from the neuroenergetic model, showing that the enhanced glucose uptake during activation is consistent with neuronal activity being energetic supported by glucose oxidation.
Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial.
TLDR
This is the first controlled study indicating that creatine supplementation improves skeletal muscle function in McArdle disease.
...
...