Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans.

@article{Djurhuus2002EffectsOC,
  title={Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans.},
  author={Christian Born Djurhuus and Claus H{\o}jbjerg Gravholt and S{\o}ren Nielsen and Anette Mengel and Jens Sandahl Christiansen and Ole E Schmitz and Niels M{\o}ller},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={283 1},
  pages={
          E172-7
        }
}
Cortisol's effects on lipid metabolism are controversial and may involve stimulation of both lipolysis and lipogenesis. This study was undertaken to define the role of physiological hypercortisolemia on systemic and regional lipolysis in humans. We investigated seven healthy young male volunteers after an overnight fast on two occasions by means of microdialysis and palmitate turnover in a placebo-controlled manner with a pancreatic pituitary clamp involving inhibition with somatostatin and… 
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TLDR
In nondiabetic volunteers, a 6-h cortisol infusion was associated with a 60% increase in palmitate Ra that did not occur with saline infusion, suggesting physiological hypercortisolemia may contribute to the increased rates of lipolysis observed in humans during stress.
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