Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans.
@article{Djurhuus2002EffectsOC, title={Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans.}, author={Christian Born Djurhuus and Claus H{\o}jbjerg Gravholt and S{\o}ren Nielsen and Anette Mengel and Jens Sandahl Christiansen and Ole E Schmitz and Niels M{\o}ller}, journal={American journal of physiology. Endocrinology and metabolism}, year={2002}, volume={283 1}, pages={ E172-7 } }
Cortisol's effects on lipid metabolism are controversial and may involve stimulation of both lipolysis and lipogenesis. This study was undertaken to define the role of physiological hypercortisolemia on systemic and regional lipolysis in humans. We investigated seven healthy young male volunteers after an overnight fast on two occasions by means of microdialysis and palmitate turnover in a placebo-controlled manner with a pancreatic pituitary clamp involving inhibition with somatostatin and…
189 Citations
Additive effects of cortisol and growth hormone on regional and systemic lipolysis in humans.
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It is found that GH and cortisol stimulate systemic and regional lipolysis independently and in an additive manner when coadministered.
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- 2009
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Evidence of Subcutaneous Tissue Lipolysis Enhancement by Endogenous Cortisol in Critically Ill Patients Without Shock.
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FO, given at a moderate dose in healthy subjects prior to a very short-term low dose of a synthetic glucocorticoid, worsened its deleterious effects on insulin sensitivity, and the enhancing effect of FO on fat oxidation and AT lipolysis might be a protective effect toward an increase in fat mass.
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