Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans.

@article{Djurhuus2002EffectsOC,
  title={Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans.},
  author={Christian Born Djurhuus and Claus H{\o}jbjerg Gravholt and S{\o}ren Nielsen and Anette Mengel and Jens Sandahl Christiansen and Ole E Schmitz and Niels M{\o}ller},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={283 1},
  pages={
          E172-7
        }
}
Cortisol's effects on lipid metabolism are controversial and may involve stimulation of both lipolysis and lipogenesis. This study was undertaken to define the role of physiological hypercortisolemia on systemic and regional lipolysis in humans. We investigated seven healthy young male volunteers after an overnight fast on two occasions by means of microdialysis and palmitate turnover in a placebo-controlled manner with a pancreatic pituitary clamp involving inhibition with somatostatin and… Expand
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Cortisol withdrawal increased insulin sensitivity in terms of increased glucose oxidation and decreased endogenous glucose production; this may induce hypoglycemia in adrenocortical failure. Expand
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The data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia. Expand
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Administration of exogenous ghrelin causes insulin resistance in muscle and stimulates lipolysis; these effects are likely to be direct, although a small contribution of GH and cortisol cannot be excluded. Expand
Evidence of Subcutaneous Tissue Lipolysis Enhancement by Endogenous Cortisol in Critically Ill Patients Without Shock.
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Slow turnover of the adipose glucocorticoid pool suggests that rapid acute fluctuations in circulating cortisol are not reflected in adipose, so that 11βHSD1 activity (previously estimated to generate 9 nmol cortisol/kg · h in sc adipose) may play a relatively important role in modulating activation of glucoc Cortisol receptors. Expand
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References

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TLDR
In nondiabetic volunteers, a 6-h cortisol infusion was associated with a 60% increase in palmitate Ra that did not occur with saline infusion, suggesting physiological hypercortisolemia may contribute to the increased rates of lipolysis observed in humans during stress. Expand
Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue.
TLDR
Site-specific regulation of the enzymes of intracellular lipolysis (hormone-sensitive lipase) and intravascular lipolyzer may explain the ability of acute cortisol treatment to increase systemic glycerol and NEFA appearance rates while chronically promoting net central fat deposition. Expand
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TLDR
It is concluded that HG per se does not increase interstitial glycerol in abdominal sc adipose tissue; nor does modest hyperglycemia, during basal insulinemia and glucagonemia, influence indices of abdominal sc lipolysis. Expand
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TLDR
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TLDR
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TLDR
It is shown that a physiological pulse of GH increases interstitial glycerol concentrations in both femoral and abdominal adipose tissue, indicating activated lipolysis. Expand
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TLDR
Interstitial glycerol remains higher in the obese than in the lean subjects also after an oral glucose load, but the regional differences were less apparent and suggest that lipolysis is enhanced in the abdominal subcutaneous tissue as compared with the femoral site in obese subjects. Expand
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TLDR
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TLDR
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TLDR
The results confirm previous findings that cortisol, in the presence of insulin, has a marked stimulatory effect on LPL activity in human adipose tissue in vitro. Expand
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