Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans.

@article{Djurhuus2002EffectsOC,
  title={Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans.},
  author={Christian Born Djurhuus and Claus H{\o}jbjerg Gravholt and S{\o}ren Nielsen and Anette Mengel and Jens Sandahl Christiansen and Ole E Schmitz and Niels M{\o}ller},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={283 1},
  pages={
          E172-7
        }
}
Cortisol's effects on lipid metabolism are controversial and may involve stimulation of both lipolysis and lipogenesis. This study was undertaken to define the role of physiological hypercortisolemia on systemic and regional lipolysis in humans. We investigated seven healthy young male volunteers after an overnight fast on two occasions by means of microdialysis and palmitate turnover in a placebo-controlled manner with a pancreatic pituitary clamp involving inhibition with somatostatin and… Expand
Additive effects of cortisol and growth hormone on regional and systemic lipolysis in humans.
TLDR
It is found that GH and cortisol stimulate systemic and regional lipolysis independently and in an additive manner when coadministered. Expand
In vivo effects of corticotropin-releasing hormone on femoral adipose tissue metabolism in women
TLDR
The importance of CRH on human energy metabolism is underlined by the present in vivo study demonstrating peptidergic effects on lipolysis and glucose homeostasis in human subcutaneous adipose tissue. Expand
Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans.
TLDR
High dose GC administration to humans leads to pro-lipolytic alterations of CGI-58, G0S2 and ANGPTL4 mRNA transcripts, increases PKA signaling to lipolysis and inhibits the insulin signal in adipose tissue. Expand
Acute Hypercortisolemia Exerts Depot-Specific Effects on Abdominal and Femoral Adipose Tissue Function
TLDR
Acute hypercortisolemia induces differential lipolysis and ATBF responses in abdominal and femoral adipose tissue, suggesting depot-specific glucocorticoid effects. Expand
Effects of cortisol on carbohydrate, lipid, and protein metabolism: studies of acute cortisol withdrawal in adrenocortical failure.
TLDR
Cortisol withdrawal increased insulin sensitivity in terms of increased glucose oxidation and decreased endogenous glucose production; this may induce hypoglycemia in adrenocortical failure. Expand
Direct effect of glucocorticoids on lipolysis in adipocytes.
TLDR
It is shown that elevated FFA concentration in plasma is associated with increased lipase activity and lipolysis in vivo in adipose tissues of dexamethasone-treated rats, which could be a cellular basis of systemic FFA elevation in response to glucocorticoid challenge. Expand
Interleukin-6 stimulates lipolysis and fat oxidation in humans.
TLDR
The data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia. Expand
Acute effects of ghrelin administration on glucose and lipid metabolism.
TLDR
Administration of exogenous ghrelin causes insulin resistance in muscle and stimulates lipolysis; these effects are likely to be direct, although a small contribution of GH and cortisol cannot be excluded. Expand
Evidence of Subcutaneous Tissue Lipolysis Enhancement by Endogenous Cortisol in Critically Ill Patients Without Shock.
TLDR
It is interesting that an association between tissue lipolysis (via MD glycerol levels) and MD cortisol is observed, verifying (although modestly so) the well-known association betweenlipolysis and cortisol. Expand
Glucocorticoids turn over slowly in human adipose tissue in vivo.
TLDR
Slow turnover of the adipose glucocorticoid pool suggests that rapid acute fluctuations in circulating cortisol are not reflected in adipose, so that 11βHSD1 activity (previously estimated to generate 9 nmol cortisol/kg · h in sc adipose) may play a relatively important role in modulating activation of glucoc Cortisol receptors. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Stimulation of Lipolysis in Humans by Physiological Hypercortisolemia
TLDR
In nondiabetic volunteers, a 6-h cortisol infusion was associated with a 60% increase in palmitate Ra that did not occur with saline infusion, suggesting physiological hypercortisolemia may contribute to the increased rates of lipolysis observed in humans during stress. Expand
Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue.
TLDR
Site-specific regulation of the enzymes of intracellular lipolysis (hormone-sensitive lipase) and intravascular lipolyzer may explain the ability of acute cortisol treatment to increase systemic glycerol and NEFA appearance rates while chronically promoting net central fat deposition. Expand
Physiological levels of glucagon do not influence lipolysis in abdominal adipose tissue as assessed by microdialysis.
TLDR
It is concluded that HG per se does not increase interstitial glycerol in abdominal sc adipose tissue; nor does modest hyperglycemia, during basal insulinemia and glucagonemia, influence indices of abdominal sc lipolysis. Expand
Effects of cortisol and growth hormone on lipolysis in human adipose tissue.
TLDR
Cortisol and GH have opposite effects on the basal lipolytic activity in human adipose tissue in vitro as well as on the sensitivity to catecholamines, GH being the lipolyic and cortisol the antilipolytic agent. Expand
Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans.
TLDR
The circadian variation in cortisol concentration is of physiologic significance in normal humans and appears to result from a state of "physiologic" insulin resistance. Expand
Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue.
TLDR
It is shown that a physiological pulse of GH increases interstitial glycerol concentrations in both femoral and abdominal adipose tissue, indicating activated lipolysis. Expand
Interstitial glycerol concentration measured by microdialysis in two subcutaneous regions in humans.
TLDR
Interstitial glycerol remains higher in the obese than in the lean subjects also after an oral glucose load, but the regional differences were less apparent and suggest that lipolysis is enhanced in the abdominal subcutaneous tissue as compared with the femoral site in obese subjects. Expand
Insulin Regulation of Lipolysis in Nondiabetic and IDDM Subjects
TLDR
It is concluded that adipose tissue lipolysis is normally exquisitely sensitive to insulin and that sensitivity, but not responsiveness to insulin, is impaired in poorly controlled IDDM. Expand
Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes.
TLDR
Hormone-sensitive lipase (HSL) mediates the lipolysis of triacylglycerol from mammalian adipocytes, resulting in the release of non-esterified fatty acids and glycerol and the measurement of HSL mRNA levels in response to hormonal regulators was studied. Expand
The effects of cortisol on the regulation of lipoprotein lipase activity in human adipose tissue.
TLDR
The results confirm previous findings that cortisol, in the presence of insulin, has a marked stimulatory effect on LPL activity in human adipose tissue in vitro. Expand
...
1
2
3
4
...