Effects of cortisol on cell proliferation and proteoglycan synthesis and degradation in cartilage zones of the calf costochondral growth plate in vitro with and without rat plasma somatomedin activity.


The actions of cortisol were investigated in vitro on separated zones of cartilage from the calf costochondral junction, and from the structural costal cartilage. Cortisol had no direct effect in plasma-free medium on the uptake of [3H]thymidine, [3H]leucine or [35S]sulphate in any zone of growth plate or structural cartilage until pharmacological… (More)


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