Effects of corticotropin releasing factor, desipramine and haloperidol on a DRL schedule of reinforcement.

@article{Britton1989EffectsOC,
  title={Effects of corticotropin releasing factor, desipramine and haloperidol on a DRL schedule of reinforcement.},
  author={Karen Thatcher Britton and George F. Koob},
  journal={Pharmacology, biochemistry, and behavior},
  year={1989},
  volume={32 4},
  pages={967-70}
}
Rats were trained on a schedule of differential-reinforcement-of-low-rate (DRL) which has been proposed to be differentially sensitive to antidepressant drugs. Desipramine and haloperidol decreased response rate and increased reinforcement rate. CRF decreased response rate and failed to change reinforcement rate. Amphetamine produced the opposite pattern of increased response rate and decreased reinforcement rate. These results question the specificity of the DRL task as a screen for… CONTINUE READING

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