Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease.

@article{Wuwongse2013EffectsOC,
  title={Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease.},
  author={Suthicha Wuwongse and Sally Shuk-Yee Cheng and Ginger Tsz-Hin Wong and Clara Hiu-Ling Hung and Natalie Qishan Zhang and Yuen-Shan Ho and Andrew Chi-Kin Law and Raymond Chuen-Chung Chang},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1832 12},
  pages={2245-56}
}
The relationship between Alzheimer's disease (AD) and depression has been well established in terms of epidemiological and clinical observations. Depression has been considered to be both a symptom and risk factor of AD. Several genetic and neurobiological mechanisms have been described to underlie these two disorders. Despite the accumulating knowledge on this topic, the precise neuropathological mechanisms remain to be elucidated. In this study, we propose that synaptic degeneration plays an… CONTINUE READING
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  • T. Spires-Jones, S. Knafo
  • plasticity, and cognition in Alzheimer's model…
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