Effects of core histone tail domains on the equilibrium constants for dynamic DNA site accessibility in nucleosomes.

Abstract

The N and C-terminal tail domains of the core histones play important roles in gene regulation, but the mechanisms through which they act are not known. These tail domains are highly positively charged and are the sites of numerous post-translational modifications, including many sites for lysine acetylation. Nucleosomes in which these tail domains have… (More)

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Cite this paper

@article{Polach2000EffectsOC, title={Effects of core histone tail domains on the equilibrium constants for dynamic DNA site accessibility in nucleosomes.}, author={Kevin J Polach and Peggy T. Lowary and Jennifer Widom}, journal={Journal of molecular biology}, year={2000}, volume={298 2}, pages={211-23} }