Effects of copper and zinc on chondrocyte-mononuclear cell adhesion via ICAM-1/CD18 interactions

@article{Pasqualicchio2007EffectsOC,
  title={Effects of copper and zinc on chondrocyte-mononuclear cell adhesion via ICAM-1/CD18 interactions},
  author={M. Pasqualicchio and Mike E. Davies and Giancarlo P Velo},
  journal={InflammoPharmacology},
  year={2007},
  volume={3},
  pages={35-48}
}
Copper and zinc play important, but as yet undetermined, roles in the function of the immune system and in inflammatory processes. In this study we demonstrated that addition of copper salts to cultures of rat and human articular cartilage and isolated porcine chondrocytes induced expression of the intercellular adhesion molecule, ICAM-1. Expression of this adhesion molecule in response to copper sulphate did not, however, promote adhesion of chondrocytes to peripheral blood mononuclear cells… CONTINUE READING