Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle

@article{Miranda2007EffectsOC,
  title={Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle},
  author={L. Miranda and S. Horman and I. D. Potter and L. Hue and J. Jensen and M. Rider},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2007},
  volume={455},
  pages={1129-1140}
}
  • L. Miranda, S. Horman, +3 authors M. Rider
  • Published 2007
  • Medicine, Chemistry
  • Pflügers Archiv - European Journal of Physiology
  • In rat epitrochlearis skeletal muscle, contraction inhibited the basal and insulin-stimulated rates of protein synthesis by 75 and 70%, respectively, while increasing adenosine monophosphate-activated protein kinase (AMPK) activity. Insulin, on the other hand, stimulated protein synthesis (by 30%) and increased p70 ribosomal protein S6 kinase (p70S6K) Thr389, 40S ribosomal protein S6 (rpS6) Ser235/236, rpS6 Ser240/244 and eukaryotic initiation factor-4E-binding protein-1 (4E-BP1) Thr37/46… CONTINUE READING
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