Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats.

@article{Yamamoto2013EffectsOC,
  title={Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats.},
  author={Masaki Yamamoto and Hiroko Jokura and Atsushi Suzuki and Tadashi Hase and Akira Shimotoyodome},
  journal={Journal of nutritional science and vitaminology},
  year={2013},
  volume={59 5},
  pages={470-3}
}
Hesperidin (HES) and glucosyl hesperidin (GHES) have antihypertensive effects. In the present study, to clarify the antihypertensive mechanisms, we compared the effects of continuous ingestion of HES and GHES in spontaneously hypertensive rats (SHRs). HES and GHES ingestion for 8 wk significantly prevented hypertension and suppressed the mRNA expression of NADPH oxidase subunits and thromboxane A2 synthase in SHR aortas. Further, hesperetin, a common metabolite of HES and GHES, reduced… CONTINUE READING