Effects of concomitant fluvoxamine on the metabolism of alprazolam in Japanese psychiatric patients: interaction with CYP2C19 mutated alleles

@article{Suzuki2003EffectsOC,
  title={Effects of concomitant fluvoxamine on the metabolism of alprazolam in Japanese psychiatric patients: interaction with CYP2C19 mutated alleles},
  author={Y. Suzuki and T. Shioiri and T. Muratake and Y. Kawashima and S. Sato and Mieko Hagiwara and Y. Inoue and K. Shimoda and T. Someya},
  journal={European Journal of Clinical Pharmacology},
  year={2003},
  volume={58},
  pages={829-833}
}
  • Y. Suzuki, T. Shioiri, +6 authors T. Someya
  • Published 2003
  • Medicine
  • European Journal of Clinical Pharmacology
  • ObjectivesAdministration of fluvoxamine (FLV) with concomitant benzodiazepines is common in clinical situations. We studied the effects of the coadministration of FLV on plasma concentrations of alprazolam (ALP). We also studied the effects ofCYP2C19*2 orCYP2C19*3 on these drug interactions.MethodsThe subjects were 23 Japanese outpatients all concomitantly treated with FLV either before or after monotherapy with ALP. We measured the plasma concentrations of ALP and FLV using a column-switching… CONTINUE READING

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