Effects of concentration and steric configuration of propranolol on AV conduction and ventricular repolarization in the dog.

@article{Brorson1981EffectsOC,
  title={Effects of concentration and steric configuration of propranolol on AV conduction and ventricular repolarization in the dog.},
  author={Leif Brorson and Sam Reele and William D. Dupont and Raymond David Woosley and Duncan Shand and Re'gie Smith},
  journal={Journal of cardiovascular pharmacology},
  year={1981},
  volume={3 4},
  pages={692-703}
}
To investigate the electrophysiological effects of propranolol in vivo over a wide range of plasma concentrations and to distinguish effects due to beta-blockade from those due to a direct membrane action, His bundle electrograms were recorded, and ventricular effective refractory periods (VERP) and monophasic action potential duration (MAP) were measured in anesthetized control dogs and in dogs given three graded infusions of d- or dl-propranolol. Dogs were excluded if the plasma… CONTINUE READING

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