Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, Vitamin B12, folic acid and Vitamin B6

  title={Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, Vitamin B12, folic acid and Vitamin B6},
  author={Ufuk Şener and Yaşar Zorlu and Oguz Karaguzel and O. Ozdamar and Işıl Çoker and Murat Topbaş},

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Plasma homocysteine and aminothiol levels in idiopathic epilepsy patients receiving antiepileptic drugs

The results suggest that redox homeostasis may be impaired and glutathione synthesis increased in response to the oxidative stress caused by antiepileptic drug use.

Homocysteine plasma levels in patients treated with antiepileptic drugs depend on folate and vitamin B12 serum levels, but not on genetic variants of homocysteine metabolism

Data suggest that, in AED-treated patients, folate and vitamin B12 play important roles in the development of hyperhomocysteinemia, whereas genetic variants of homocysteine metabolism do not and thus do not contribute to the risk of developing hyperHomocysteemia during AED treatment.

The effect of antiepileptic drugs on vitamin B12 metabolism

The effects of antiepileptic drugs (AED) on the serum concentration of vitamin B12, folic acid and homocysteine (HMC), and erythrocyte folic Acid levels and peripheral blood smear findings did not correlate with the drugs used.

Estimation of Serum Level of Homocysteine and its Potential Cardiovascular Effect in Epileptic Children Receiving Antiepileptic Drugs

This study revealed statically significant increase serum level of homocysteine, carotid intima media thickness andCarotid stiffness in children on monotherapy of old generation antiepileptic drugs and poly therapy than that inChildren on mon Therapy of new generation antIEpileptic drugs and control.

Efficacy Study of Folic Acid Supplementation on Homocysteine Levels in Adolescent Epileptics Taking Antiepileptic Drugs: A Single Blind Randomized Controlled Clinical Trial

The study results suggest that FA supplementation in epileptic patients receiving AED therapy may minimize AED-induced hyperhomocysteinemia and other CVD risk factors.

Lipid and homocysteine levels in epileptic children treated with valproic acid – a preliminary data

Valproic acid used for at least 6 months may cause elevation of plasma homocysteine level as well as serum lipids levels in children with epilepsy, and further studies are needed to confirm this preliminary findings.

To determine the effect of long-term antiepileptic drug on the serum folate and vitamin B12 among epileptic patients

The experimental results have proved that a long-term phenytoin treatment significantly affects the concentration of Folate and Vitamin B12 among the Epileptic patients vigorously.



Anti-epileptic drug treatment in children: hyperhomocysteinaemia, B-vitamins and the 677C-->T mutation of the methylenetetrahydrofolate reductase gene.

  • M. VilasecaE. Monrós M. Pineda
  • Medicine, Psychology
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
  • 2000
The lowering action of carbamazepine treatment on folate levels seems to be associated with hyperhomocysteinaemia, which appears to be related to the homozygous condition for the MTHFR 677C-->T mutation.

Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy

Plasma homocysteine and lipoprotein (a) levels as risk factors for atherosclerotic vascular disease in epileptic children taking anticonvulsants

A significant inverse relationship was found between vitamin B12 folate levels and plasma homocysteine levels in the patient group; 28.8% of the patient groups had lipoprotein concentrations above the cutoff value for increased risk of early atherosclerosis, whereas none of the control patients had concentrations above this value.

Plasma total homocysteine concentrations in epileptic patients taking anticonvulsants.

Elevated Plasma Concentrations of Homocysteine in Antiepileptic Drug Treatment

The objective of the study was to test the hypothesis that antiepileptic drug (AED) treatment is associated with increased homocysteine plasma concentrations.

Folate, homocysteine and methionine loading in patients on carbamazepine

The methionine loading test identified additional patients with hyperhomocysteinemia undetected by fasting p‐tHcy in patients on carbamazepine (CBZ), suggesting CBZ therapy may be associated with low folate and high p‐ tHcy levels.