Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells.

@article{Fisher1985EffectsOC,
  title={Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells.},
  author={Paul B Fisher and D R Prignoli and H Hermo and I. Bernard Weinstein and Sidney Pestka},
  journal={Journal of interferon research},
  year={1985},
  volume={5 1},
  pages={11-22}
}
We have analyzed the effects of various human interferons produced in bacteria and the antileukemic compound mezerein (MEZ) on growth and melanogenesis in human melanoma cells. In four human melanoma cell lines, recombinant human fibroblast interferon (IFN-beta) was more active than recombinant human leukocyte interferons (IFN-alpha A, IFN-alpha D, or IFN-alpha A/D (Bgl] in inhibiting cellular proliferation. When monolayer cultures were exposed to 1000 IU/ml IFN-beta for four days the degree of… CONTINUE READING