Effects of combined treatment with imipramine and metyrapone in the forced swimming test in rats. Behavioral and pharmacokinetic studies.

@article{Rog2003EffectsOC,
  title={Effects of combined treatment with imipramine and metyrapone in the forced swimming test in rats. Behavioral and pharmacokinetic studies.},
  author={Zofia Rog{\'o}ż and Grażyna Skuza and Jacek W{\'o}jcikowski and Włakysława A Daniel},
  journal={Polish journal of pharmacology},
  year={2003},
  volume={55 6},
  pages={993-9}
}
In the present study, we examined the effects of imipramine (IMI) and metyrapone (MET) given alone or in combination of IMI and MET in the forced swimming test in rats. We also measured pharmacokinetic parameters: the level of IMI and its metabolite, desipramine (DMI), in the rat plasma and brain (1 h after the forced swimming test). The present studies indicate that MET (50 mg/kg) reduced immobility time. Combined treatment with MET (50 mg/kg) and IMI (5 or 10 mg/kg) produced stronger… CONTINUE READING
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