Effects of combinations of beta-lactams, daptomycin, gentamicin, and glycopeptides against glycopeptide-resistant enterococci

@article{Leclercq1991EffectsOC,
  title={Effects of combinations of beta-lactams, daptomycin, gentamicin, and glycopeptides against glycopeptide-resistant enterococci},
  author={Roland Leclercq and Edouard Bingen and Q H Su and N Lambert-Zechovski and Patrice Courvalin and Jean Duval},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1991},
  volume={35},
  pages={92 - 98}
}
Activities of combinations of beta-lactams, daptomycin, gentamicin, teicoplanin, and vancomycin against 11 clinical isolates of Enterococcus faecium highly resistant to glycopeptides, three plasmid-cured derivatives, eight E. faecalis and E. faecium transconjugants, and two susceptible recipient strains were tested. A marked synergy between penicillins or imipenem and glycopeptides against the glycopeptide-resistant strains but not against the glycopeptide-susceptible strains was observed by… Expand
Comparison of different beta-lactam-glycopeptide-gentamicin combinations for an experimental endocarditis caused by a highly beta-lactam-resistant and highly glycopeptide-resistant isolate of Enterococcus faecium.
TLDR
In rabbits, after a 5-day treatment, the ceftriaxone-vancomycin-gentamicin combination was the most effective, both in reducing the total bacterial titers and in eradicating the subpopulation resistant to the synergy. Expand
Synergy and resistance to synergy between beta-lactam antibiotics and glycopeptides against glycopeptide-resistant strains of Enterococcus faecium.
TLDR
Observations reflect the relationship which seems to exist between the new D-lactate peptidoglycan precursor, synthesized when the vancomycin resistance is expressed, and the affinity of the different PBPs for this precursor. Expand
Antimicrobial interactions (synergy) of teicoplanin with two broad-spectrum drugs (cefotaxime, ofloxacin) tested against gram-positive isolates from Germany and the United States.
TLDR
Teicoplanin continues to be a viable alternative to vancomycin, especially in combination therapy with selected broad-spectrum cephalosporins or fluoroquinolones, and many emerging pathogens that test resistant to individual drugs appear to be inhibited by tested combinations, extending their potential clinical utility. Expand
In Vitro Activity of Daptomycin in Combination with β-Lactams, Gentamicin, Rifampin, and Tigecycline against Daptomycin-Nonsusceptible Enterococci
TLDR
Ampicillin plus daptomycin yielded the most consistent synergy but did so only for isolates with mutations to the liaFSR system, adding support to the growing body of evidence indicating that therapy combining daptomecin and ampicillin may be helpful in eradicating refractory VRE infections. Expand
In vitro prevention of the emergence of daptomycin resistance in Staphylococcus aureus and enterococci following combination with amoxicillin/clavulanic acid or ampicillin.
TLDR
Addition of amoxicillin/clavulanic acid or ampicillin to daptomycin prevents, or greatly delays, d aptomycin resistance in vitro, and future studies in animal models are needed to predict the utility of these combinations in humans. Expand
Evaluation of In Vitro Interaction of Daptomycin with Gentamicin or Beta-lactam Antibiotics Against taphylococcus aureus and Enterococci by FIC Index and Timed-Kill Curves
TLDR
The in vitro data suggest that daptomycin combined with other antibiotics may be microbiologically beneficial and not antagonistic. Expand
Bactericidal activities of antibiotics against vancomycin-resistant Enterococcus faecium blood isolates and synergistic activities of combinations
TLDR
Overall, bactericidal activity was attainable against 7 of 13 VRE isolates at 24 h and there was a trend toward improved killing of some HLGR V RE isolates by teicoplanin plus imipenem. Expand
Serum Bactericidal Activities of High-Dose Daptomycin with and without Coadministration of Gentamicin against Isolates of Staphylococcus aureus and Enterococcus species
TLDR
The results of this study suggest that the addition of gentamicin does not alter the pharmacokinetic profile or enhance the bactericidal activity of daptomycin against staphylococcal or enterococcal isolates. Expand
Two-Step Acquisition of Resistance to the Teicoplanin-Gentamicin Combination by VanB-Type Enterococcus faecalis In Vitro and in Experimental Endocarditis
TLDR
Results suggest that two mutations are also required to suppress the in vivo activity of the teicoplanin-gentamicin combination, and this regimen prevented the emergence of mutants resistant to one or both components of the combination. Expand
Impact of Daptomycin Dose Exposure Alone or in Combination with β-Lactams or Rifampin against Vancomycin-Resistant Enterococci in an In Vitro Biofilm Model
TLDR
The authors' data provide further support for the use of combinations of DAP with AMP, ERT, CPT, and RIF in infections caused by biofilm producing VREfm and further research involving DAP combinations against biofilm-producing enterococci is warranted. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 23 REFERENCES
Transferable vancomycin and teicoplanin resistance in Enterococcus faecium
TLDR
Based on this first report of transferable resistance to glycopeptides, it is anticipated that dissemination of resistance to these antibiotics in gram-positive cocci and bacilli in which it can be phenotypically expressed is expected. Expand
Species-specific resistance to antimocrobial synergism in Streptococcus faecium and Streptococcus faecalis.
TLDR
Resistance to in vitro synergism by combinations of penicillin and various aminoglycosides is found and the possible clinical significance of these findings was verified by use of the rabbit model of endocarditis. Expand
Inducible, transferable resistance to vancomycin in Enterococcus faecalis A256
TLDR
It is concluded that Enterococcus faecalis A256 is resistant to glycopeptides by virtue of the synthesis of a 39-kDa cytoplasmic membrane protein, that this protein is probably involved in preventing access of the glycopesptides to their peptidoglycan targets, and that this resistance is transferable, probably by conjugation. Expand
In vitro susceptibility studies of vancomycin-resistant Enterococcus faecalis
TLDR
To detect vancomycin resistance reliably and establish the incidence of such E. faecalis isolates, adjustments in some susceptibility testing methods may be necessary. Expand
Phenotypic and genotypic heterogeneity of glycopeptide resistance determinants in gram-positive bacteria
TLDR
Gram-positive glycopeptide-resistant bacteria isolated in various hospitals in Europe and in the United States between 1986 and 1988 were collected, suggesting that spread of this resistance phenotype is due to dissemination of a gene rather than of a bacterial clone or of a single plasmid. Expand
Activity of LY146032 against Enterococci with and without high-level aminoglycoside resistance, including two penicillinase-producing strains
TLDR
In time-kill assays, a 2 to 3 log10 killing effect was observed with LY against two Bla+ strains of Streptococcus (Enterococcus) faecalis and against three strains that were highly resistant to streptomycin and gentamicin. Expand
Inducible resistance to vancomycin in Enterococcus faecium D366.
TLDR
It is concluded that vancomycin resistance in D366 is inducible; resistance is correlated with the synthesis of 39.5-kDa cytoplasmic membrane protein, which plays an additional role in the inhibition of normal lytic functions. Expand
Mechanism of resistance to vancomycin in Enterococcus faecium D366 and Enterococcus faecalis A256
TLDR
It is hypothesize that the inducible proteins are responsible for glycopeptide resistance due to the binding to, and subsequent enzymatic modification of, the pentapeptide precursor of peptidoglycan, which is considered to be the natural target of glycopesptides. Expand
The life and times of the Enterococcus
  • B. Murray
  • Medicine, Biology
  • Clinical Microbiology Reviews
  • 1990
TLDR
Enterococci are important human pathogens that are increasingly resistant to antimicrobial agents, including resistance to cephalosporins, clindamycin, tetracycline, and penicillinase-resistant penicillins such as oxacillin, among others. Expand
The antibacterial action of vancomycin.
TLDR
There is evidence that vancomycin inhibits the second stage of cell wall synthesis in susceptible bacteria and alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis. Expand
...
1
2
3
...