Effects of streptozotocin/bis-chloroethylnitrosourea combination therapy on O6-methylguanine DNA methyltransferase activity and mRNA levels in HT-29 cells in vitro.

@article{Pieper1991EffectsOS,
  title={Effects of streptozotocin/bis-chloroethylnitrosourea combination therapy on O6-methylguanine DNA methyltransferase activity and mRNA levels in HT-29 cells in vitro.},
  author={Russell O. Pieper and Bernard W. Futscher and Qihan Dong and Leonard C. Erickson},
  journal={Cancer research},
  year={1991},
  volume={51 6},
  pages={
          1581-5
        }
}
Treatment of chloroethylnitrosourea-resistant cells with streptozotocin (STZ) prior to bis-chloroethylnitrosourea (BCNU) exposure has been shown to result in a depletion of O6-methylguanine DNA methyltransferase (MGMT) activity, increased BCNU-induced interstrand cross-linking, and a 2-3 log enhancement of BCNU cytotoxicity in vitro. The current study was undertaken to define the kinetics of repletion of MGMT activity following the STZ/BCNU combination and to assess at the molecular level the… CONTINUE READING

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SHOWING 1-10 OF 33 REFERENCES

O6Methylguanine-DNA methyltransferase in human cells

  • S Mitra.
  • Mutât. Res.,
  • 1984
Highly Influential
5 Excerpts

Potentiation of nitrosourea cyto1584 Research

  • E Gerson.S.L..Trey.J., K Miller.
  • on September
  • 1991
2 Excerpts

Comparison of W-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mere and Mer human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique

  • L C.Erickson.
  • Cancer Commun.
  • 1990
3 Excerpts

Preclinical and clinical experi ences with drug combinations designed to inhibit DNA repair enzymes

  • K Erickson.L.C..Micetich., R Fisher.
  • Mechanisms of Drug Resistance in Neoplastic Cells
  • 1988
2 Excerpts

V. Measurement of O6alkylguanine-DNA alkyltransferasc activity in human cells and tumor tissue by restriction endonuclease inhibition

  • R S.VVu., S.. Hurst-Calderone, K. Kohn
  • Cancer Res.
  • 1987
2 Excerpts

Combined effect of streptozotocin and mitozolomide against four human cell lines of the Mer+ phenotype

  • C Erickson.L.
  • Cancer Res.
  • 1986

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