Effects of combination of low doses of angiotensin-converting enzyme inhibitor and diuretics on renal function in spontaneously hypertensive rats: comparison between acute and chronic treatment

@article{Doucet2001EffectsOC,
  title={Effects of combination of low doses of angiotensin-converting enzyme inhibitor and diuretics on renal function in spontaneously hypertensive rats: comparison between acute and chronic treatment},
  author={J Doucet and Vincent Richard and Paul Mulder and Jean Paul Henry and Pierre Schiavi and David Guez and Christian Thuillez},
  journal={Journal of the Renin-Angiotensin-Aldosterone System},
  year={2001},
  volume={2},
  pages={107 - 111}
}
The goal of this study was to assess the effect of acute or chronic treatment with S5590, a combination of the angiotensin-converting enzyme inhibitor perindopril (0.76 mg/kg/day) and the diuretic indapamide (0.24 mg/kg/day) on renal function in spontaneously hypertensive rats with moderate renal injury. Renal function was evaluated in conscious rats by clearance methods using labelled inulin and PAH, after catheterisation of the carotid artery, jugular vein and bladder. Both acute and chronic… 

Figures and Tables from this paper

Indapamide-induced prevention of myocardial fibrosis in spontaneous hypertension rats is not nitric oxide-related.
TLDR
The results indicate that indapamide-induced prevention of myocardial fibrosis is not mediated by nitric oxide-related mechanism.

References

SHOWING 1-10 OF 28 REFERENCES
Fixed-dose combination of perindopril with indapamide in spontaneously hypertensive rats: haemodynamic, biological and structural effects
TLDR
In isolated aortae, chronic combined drug treatment was associated with an increased basal release of nitric oxide and a decrease in the hypertension-induced endothelium-dependent contractions in response to acetylcholine.
Effect of indapamide on volume-dependent hypertension, renal haemodynamics, solute excretion and proximal nephron fractional reabsorption in the dog.
TLDR
Results indicate that, at doses up to 3.0 mg/kg, indapamide causes a natriuresis which is modest and similar to that seen with thiazides, and this drug apparently exerts an inhibition of solute reabsorption in both the proximal nephron and the cortical diluting segment.
Acute blood pressure and urinary responses to single dose combinations of captopril and diuretics in conscious spontaneously hypertensive rats
TLDR
Concomitant measurement of BP and urinary excretion in conscious, freely‐moving SHR is a useful technique for studying new antihypertensive drugs and it was found that enhancement of the acute hypotensive response to captopril with concomitant diuretic therapy occurs within 10 min and is primarily related to the fluid and Na loss, regardless of the diuretics used.
Combination of converting enzyme inhibitor with diuretic for the treatment of hypertension.
TLDR
The combination of converting enzyme inhibitor and diuretic provides an ideal choice in terms of efficacy, compliance, side effects, and cost.
Antihypertensive Effects of Captopril in Combination with Diuretics in Spontaneously Hypertensive Rats
TLDR
It is suggested that repeated administration of diuretics renders the maintenance of blood pressure more dependent on the renin-angiotensin system without affecting blood pressure and that this situation underlies the potentiation of the antihypertensive action of captopril by combined use of diUREtics.
Perindopril, a New Converting Enzyme Inhibitor: Systemic and Regional Hemodynamics and Sympathoinhibitory Effects in Spontaneously Hypertensive Rats
TLDR
Results indicate that perindopril lowers BP in SHRs by a renal-dependent mechanism, and exerts inSHRs a sympathoinhibitory effect versus α-adrenoceptor agonists and spinal cord stimulation, which is possibly prejunctional in its mechanism and does not require the presence of the kidneys.
Renal hemodynamics in the rat before and during inhibition of angiotensin II.
TLDR
Data indicate that angiotensin II modifies base-line RBF and renal vascular resistance and are consistent with the view that the renin-angiotens in system is not an essential mechanism responsible for autoregulation of RBF in the rat.
Renin-angiotensin system, converting-enzyme inhibition and kidney function in aging female rats.
TLDR
The results indicate that the activity of the renin-angiotensin system is progressively reduced with age and suggest that angiotens in II does not play an important role in the maintenance of blood pressure and kidney hemodynamics in normotensive female senescent rats.
Diuretic and cardiovascular effects of indapamide in hypertensive subjects: a dose-response curve.
TLDR
The results suggest that indapamide not only has a diuretic effect, but also acts as a veno-arterial vasodilator.
Antihypertensive action of indapamide. Comparative studies in several experimental models.
TLDR
In genetically hypertensive rats indapamide was 30-300 times more potent than furosemide, spironolactone and chlorthalidone and had no effect on blood pressure in normotensive rats.
...
1
2
3
...