Effects of cold atmospheric plasma generated in deionized water in cell cancer therapy

@article{Chen2016EffectsOC,
  title={Effects of cold atmospheric plasma generated in deionized water in cell cancer therapy},
  author={Zhitong Chen and Li Lin and Xiaoqian Cheng and Eda Gjika and Michael Keidar},
  journal={Plasma Processes and Polymers},
  year={2016},
  volume={13},
  pages={1151-1156}
}
Cold atmospheric plasma (CAP) was shown to affect cells not only directly, but also indirectly by means of plasma pre-treated solution. This study investigated a new application of CAP generated in deionized (DI) water for the cancer therapy. In our experiments, the CAP solution was generated in DI water using helium as carrier gas. We report on the effects of this plasma solution in breast (MDA-MD-231) and gastric (NCI-N87) cancer cells. The results revealed that apoptosis efficiency was… 
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43 References

Cold atmospheric plasma discharged in water and its potential use in cancer therapy

Cold atmospheric plasma (CAP) has emerged as a novel technology for cancer treatment. CAP can directly treat cells and tissue but such direct application is limited to skin or can be invoked as a…

Treatment of gastric cancer cells with nonthermal atmospheric plasma generated in water.

Findings show that the plasma generated in DI water with 30-min duration has the strongest effect on apoptosis in precultured human gastric cancer cells, and elevated levels of RNS may play a more significant role than ROS in the rate of cell death.

Controlling plasma stimulated media in cancer treatment application

This study demonstrated the significant role of media in killing cancer cells via the CAP treatment by altering the concentration of fetal bovine serum in Dulbecco's modified Eagle's medium and the temperature to store CAP stimulated media.

Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy

The development of cold plasma tumour ablation has the potential of shifting the current paradigm of cancer treatment and enabling the transformation ofcancer treatment technologies by utilisation of another state of matter.

Principles of using Cold Atmospheric Plasma Stimulated Media for Cancer Treatment

Using larger wells on a multi-well plate, smaller gaps between the plasma source and the media and smaller media volume enabled to obtain a stronger anti-cancer CAPs media composition without increasing the treatment time, and cysteine was the main target of effective reactive species in theCAPs media.

Cold atmospheric plasma for the ablative treatment of neuroblastoma.

Plasma in Cancer Treatment

Anti-Cancer Therapies of 21st Century: Novel Approach to Treat Human Cancers Using Cold Atmospheric Plasma

These effects support the potential direct (CAP) and indirect (CAP-activated media) applications for adjuvant anti-cancer therapeutics, in a combination with the chemo-, radio-, and nano-therapies.

Cytotoxic and mutagenic potential of solutions exposed to cold atmospheric plasma

Plasma-treated foetal bovine serum acting as a model for complex bio-fluids showed not only cytotoxic effects but also exhibited increased mutagenic potential as determined using the mammalian HPRT assay.

Effects of atmospheric nonthermal plasma on invasion of colorectal cancer cells.

Treatment of cancer cells with the plasma jet resulted in a decrease in cell migrationinvasion with higher plasma intensity and the addition of oxygen to the He flow gas.