Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea‐pig

@article{Adcock1988EffectsOC,
  title={Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea‐pig},
  author={J. Adcock and C. Schneider and T. Smith},
  journal={British Journal of Pharmacology},
  year={1988},
  volume={93}
}
1 Antitussive, antinociceptive and respiratory depressant effects of codeine, morphine and H.Tyr.d>‐Arg.Gly.Phe(4‐NO2) Pro.NH2 (compound BW443C) were investigated in unanaesthetized guinea‐pigs. Antagonism of the antitussive and antinociceptive effects was investigated by the use of nalorphine and N‐methylnalorphine. Naloxone was used to antagonize respiratory depression. 2 Antitussive ED50s (with 95% confidence limits) for inhibition of cough induced by citric acid vapour were for codeine… Expand
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