Effects of cocaine history on postsynaptic GABA receptors on dorsal raphe serotonin neurons in a stress-induced relapse model in rats.

@article{Li2016EffectsOC,
  title={Effects of cocaine history on postsynaptic GABA receptors on dorsal raphe serotonin neurons in a stress-induced relapse model in rats.},
  author={Chen Li and Lynn G. Kirby},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2016},
  volume={26 1},
  pages={45-54}
}
The serotonin (5-hydroxytryptamine, 5-HT) system plays an important role in stress-related psychiatric disorders and substance abuse. Stressors and stress hormones can inhibit the dorsal raphe nucleus (DRN)-5-HT system, which composes the majority of forebrain-projecting 5-HT. This inhibition is mediated via stimulation of GABA synaptic activity at DRN-5-HT… CONTINUE READING