Effects of cocaine alone and in combination with mazindol in human cocaine abusers.

@article{Preston1993EffectsOC,
  title={Effects of cocaine alone and in combination with mazindol in human cocaine abusers.},
  author={K. L. Preston and John T. Sullivan and Petra Berger and George E. Bigelow},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={267 1},
  pages={296-307}
}
Mazindol is a catecholamine reuptake inhibitor that blocks binding of cocaine at the dopamine reuptake site. This study was conducted to determine whether the acute administration of mazindol modulates the pharmacological effects of intravenous cocaine in humans. In a crossover study, twelve acute drug conditions were tested in randomized order under double-blind, double-dummy conditions in eight cocaine abusers. Cocaine (0, 12.5, 25 and 50 mg, i.v.) was administered in combination with… CONTINUE READING

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