Effects of coadministration of artemisinin and iron on histopathologicalalterations in the AGS gastric adenocarcinoma cell line.

  title={Effects of coadministration of artemisinin and iron on histopathologicalalterations in the AGS gastric adenocarcinoma cell line.},
  author={Payman Zare and Amir Ali Shahbazfar and Mahsa Alem and Salman Varmaghani},
  journal={Turkish journal of medical sciences},
  volume={47 1},
BACKGROUND/AIM The aim of the present study was to examine the anticancer effects of combination treatment with artemisinin and iron on the human gastric cancer cell line. MATERIALS AND METHODS The AGS cell line was cultivated separately as a monolayer in culture flasks and different doses of 99% pure artemisinin with invariable doses of iron sulfate were added to the culture media and adhesive cells on the flask's bottom were stained with hematoxylin-eosin for a pathological assay. RESULTS… Expand
2 Citations
Rheum Ribes L.'nin etanol ekstrelerinin malign melanoma hücreleri üzerine anti-kanser etkinliğinin araştırılması
Bu calismanin amaci iskin bitkisinin malign melanoma hucreleri uzerine antikanser etkinliginin var oldugu ve bitkinin govde ve kabuklarina kiyasla kok ekstraktinin anti-kanser ilac olma potansiyelinin daha yuksek oldugu kanaatine varilmistir. Expand


A survey on anticancer effects of artemisinin, iron, miconazole, and butyric acid on 5637 (bladder cancer) and 4T1 (Breast cancer) cell lines.
A combination therapy with artemisinin can be more effective against cancer cells than monotherapy with that and miconazole deviated the nature of cell death from apoptosis to necrosis and it must be used under caution. Expand
Artemisinin-transferrin conjugate retards growth of breast tumors in the rat.
Artemisinin-transferrin conjugate could be developed into a potent therapeutic agent for cancer in humans after being tested in a rat breast cancer model. Expand
Effects of different concentrations of artemisinin and artemisinin-iron combination treatment on Madin Darby Canine Kidney (MDCK) cells
Biochemical parameters showed cellular reaction and injury was more severe in the iron-added groups, and on using the drug for leishmaniasis treatment in the dog, it should be done with caution and supervision. Expand
Development of artemisinin compounds for cancer treatment
Simple artemisinin analogs are less potent than traditional cancer chemotherapeutic agents and have short plasma half-lives, and would require high dosage and frequent administration to be effective for cancer treatment. Expand
Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron.
Treatment of p53 wild-type TK6 and p53 mutated WTK1 lymphoblastic cells showed that mutational status of the tumor suppressor p53 did not influence sensitivity to artesunate, indicating that artemisinins plus ferrous iron may affect tumor cells more than normal cells. Expand
[A new artemisinin derivative SM1044 induces apoptosis of Kasumi-1 cells and its mechanism].
It is concluded that SM1044 can inhibit the proliferation of Kasumi-1 cells, induce cell apoptosis which may be related to the increased level of cleaved PARP and cleaved caspase 3 and induce cell arrest in G(0)/G(1) phase. Expand
Effects of artemisinin-tagged holotransferrin on cancer cells.
A method to synthesize a 'tagged-compound' compound in which transferrin was conjugated with an analog of artemisinin artelinic acid via the N-glycoside chains on the C-domain that was found to be very potent and selective in killing cancer cells. Expand
Antimalarial and anticancer activities of artemisinin-quinoline hybrid-dimers and pharmacokinetic properties in mice.
  • M. Lombard, D. N’Da, +7 authors L. Wiesner
  • Biology, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2012
Snapshot pharmacokinetic analysis demonstrated that the antiplasmodial activity of these C-10-acetal artemisinin dimers may be due to active metabolites, which were confirmed by in silico findings. Expand
pH-Responsive Artemisinin Derivatives and Lipid Nanoparticle Formulations Inhibit Growth of Breast Cancer Cells In Vitro and Induce Down-Regulation of HER Family Members
It is demonstrated for the first time, for any ART derivative, that ADP NPs can down regulate the oncogenic protein HER2, and its counterpart, HER3 in a HER2+ cell line. Expand
The artemisinin derivative artesunate inhibits corneal neovascularization by inducing ROS-dependent apoptosis in vascular endothelial cells.
  • R. Cheng, Cen Li, +10 authors G. Gao
  • Chemistry, Medicine
  • Investigative ophthalmology & visual science
  • 2013
It is suggested that artesunate induces apoptosis of endothelial cells via an iron/ROS-dependent p38MAPK-mitochondrial pathway. Expand