Effects of clustered epitopes in multivalent ligand-receptor interactions.

@article{Dam2008EffectsOC,
  title={Effects of clustered epitopes in multivalent ligand-receptor interactions.},
  author={Tarun Kanti Dam and Curtis Brewer},
  journal={Biochemistry},
  year={2008},
  volume={47 33},
  pages={8470-6}
}
Many biological ligands are composed of clustered binding epitopes. However, the effects of clustered epitopes on the affinity of ligand-receptor interactions in many cases are not well understood. Clustered carbohydrate epitopes are present in naturally occurring multivalent carbohydrates and glycoproteins, which are receptors on the surface of cells. Recent studies have provided evidence that the enhanced affinities of lectins, which are carbohydrate binding proteins, for multivalent… CONTINUE READING

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