Effects of clozapine on latent inhibition in the rat.

@article{Moran1996EffectsOC,
  title={Effects of clozapine on latent inhibition in the rat.},
  author={P. M. Moran and ThA. Fischer and J M Hitchcock and P Moser},
  journal={Behavioural pharmacology},
  year={1996},
  volume={7 1},
  pages={42-48}
}
In the present study we have examined the effect of clozapine, an atypical antipsychotic drug, on latent inhibition (LI) using the conditioned emotional response (CER) procedure. In this procedure, ten pre-exposures to the to-be-conditioned stimulus result in weak or no LI whereas 30 pre-exposures produce robust LI. Three different experimental protocols were used to study the effects of clozapine: facilitation of LI in animals subjected to ten pre-exposures to the to-be-conditioned stimulus… CONTINUE READING

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