Effects of clozapine on behavioral and metabolic traits relevant for schizophrenia in two mouse strains

@article{Zarate2003EffectsOC,
  title={Effects of clozapine on behavioral and metabolic traits relevant for schizophrenia in two mouse strains},
  author={Jean Mary Zarate and Patricia Boksa and Trino Baptista and Ridha Joober},
  journal={Psychopharmacology},
  year={2003},
  volume={171},
  pages={162-172}
}
Schizophrenia is a heterogeneous syndrome both at the etiological and clinical levels. In particular, patients with schizophrenia exhibit important variability in their therapeutic and metabolic responses to clozapine, an antipsychotic medication. Here, we determine whether two mouse strains show differing clozapine responses with respect to weight gain, enhancement of prepulse inhibition of acoustic startle, and reversal of amphetamine-induced locomotion. Observed between-strain differences… CONTINUE READING

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