• Corpus ID: 24201237

Effects of cloxazolam and pindolol on the sympathetic and adrenal stress reaction during oral surgery in man.

@article{Brisse1981EffectsOC,
  title={Effects of cloxazolam and pindolol on the sympathetic and adrenal stress reaction during oral surgery in man.},
  author={Betty Brisse and Peter Tetsch and Afolabi Toye and E Schwill and Franz Bender},
  journal={Arzneimittel-Forschung},
  year={1981},
  volume={31 11},
  pages={
          1958-62
        }
}
In two studies including 73 patients the stress reducing effects of the tranquilizer Cloxazolam (Olcadil) and the beta-receptor-blocking drug pindolol (Visken) were investigated after the application of a single oral dose (3 mg Cloxazolam, 5 mg pindolol). The drugs were tested against placebo by the double blind method. After local anesthesia and during oral surgery an increase of dopamine-beta-hydroxylase (DBH)-activity, noradrenaline-, c-AMP-, ACTH and cortisol concentration was found in the… 
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