Effects of cloud-point grafting, chain length, and density of PEG layers on competitive adsorption of ocular proteins.

@article{Kingshott2002EffectsOC,
  title={Effects of cloud-point grafting, chain length, and density of PEG layers on competitive adsorption of ocular proteins.},
  author={Peter Kingshott and Helmut Thissen and Hans J Griesser},
  journal={Biomaterials},
  year={2002},
  volume={23 9},
  pages={
          2043-56
        }
}
The effects of pinning density, chain length, and 'cloud point' (CP) versus non-CP grafting conditions have been studied on the ability of polyethylene glycol (PEG) layers to minimize adsorption from a multicomponent (lysozyme, human serum albumin (HSA), IgG and lactoferrin) protein solution. Methoxy-terminated aldehyde-PEG (M-PEG, MW 5000) and dialdehyde-PEG (PEG(ald)2, MW 3400) were grafted by reductive amination onto two surfaces of different amine group density, generated by radiofrequency… CONTINUE READING
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