Effects of closed traumatic brain injury and genetic factors on the development of Alzheimer's disease.

@article{Jellinger2001EffectsOC,
  title={Effects of closed traumatic brain injury and genetic factors on the development of Alzheimer's disease.},
  author={Kurt A. Jellinger and Werner Paulus and Christian Wrocklage and Irene Litvan},
  journal={European journal of neurology},
  year={2001},
  volume={8 6},
  pages={707-10}
}
In order to assess the impact of traumatic brain injury (TBI) and Apolipoprotein E (ApoE) allele frequency on the development of Alzheimer's disease (AD), we examined: (i) the incidence of AD pathology in 55 consecutive autopsy cases (mean age +/- SD 77.6 +/- 7.3 years) with residual closed TBI lesions and (ii) the frequency of TBI residuals in 53 age-matched autopsy proven AD cases. In both series, ApoE was evaluated from archival paraffin-embedded brain material. The results were as follows… CONTINUE READING
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