Effects of clonidine and yohimbine on the pupillary light reflex and carbachol-evoked sweating in healthy volunteers.

@article{Morley1991EffectsOC,
  title={Effects of clonidine and yohimbine on the pupillary light reflex and carbachol-evoked sweating in healthy volunteers.},
  author={M. J. Morley and Christopher M. Bradshaw and Elem{\'e}r Szabadi},
  journal={British journal of clinical pharmacology},
  year={1991},
  volume={31 1},
  pages={
          99-101
        }
}
The effects of single doses of clonidine hydrochloride (200 micrograms), yohimbine hydrochloride (22 mg), a combination of the two treatments, and placebo, on some autonomic functions were studied in healthy volunteers using a double-blind crossover design. Clonidine prolonged the recovery time of the light reflex, lowered systolic blood pressure and reduced subjectively rated alertness; these effects were reversed by yohimbine. Responsiveness of sweat glands to carbachol was not affected by… CONTINUE READING

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