Effects of clonidine and other imidazole-receptor binding agents on second messenger systems and calcium influx in bovine adrenal chromaffin cells.

@article{Regunathan1991EffectsOC,
  title={Effects of clonidine and other imidazole-receptor binding agents on second messenger systems and calcium influx in bovine adrenal chromaffin cells.},
  author={Soundar Regunathan and Marian J. Evinger and Mary P. Meeley and Donald J. Reis},
  journal={Biochemical pharmacology},
  year={1991},
  volume={42 10},
  pages={2011-8}
}
Clonidine and related imidazoline compounds bind to alpha 2-adrenergic as well as to newly described non-adrenergic imidazole/imidazoline receptors in brain and peripheral tissues. The present study was undertaken to identify the signal transduction mechanism coupled to this new class of receptors (imidazole receptors) using bovine adrenal chromaffin cells. Clonidine did not modify the basal or forskolin-stimulated production of cyclic AMP (cAMP), suggesting the absence of functionally active… CONTINUE READING