Effects of clomiphene on various biochemical reactions in the mouse testis in vitro.

  title={Effects of clomiphene on various biochemical reactions in the mouse testis in vitro.},
  author={M A Hollinger},
  journal={Biochemical pharmacology},
  volume={20 11},
  • M. Hollinger
  • Published 1 November 1971
  • Biology, Medicine
  • Biochemical pharmacology
Abstract Clomiphene(2 × 10 −4 M) was found to inhibit mouse testis protein and RNA synthesis in vitro . The inhibition of protein synthesis was not principally the result of altered membrane transport since clomiphene had relatively little effect on the accumulation of a -aminoisobutyric acid-3- 14 C in testis. The inhibitory effect of clomiphene on protein synthesis could be reversed by the addition of glucose. The drug was found to partially reduce the oxidation of d -Glucose-U- 14 C to 14 CO… 
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