Effects of clomiphene on luteal function in the nonpregnant cynomolgus macaque.

@article{Westfahl1983EffectsOC,
  title={Effects of clomiphene on luteal function in the nonpregnant cynomolgus macaque.},
  author={Pamela K. Westfahl and John A. Resko},
  journal={Biology of reproduction},
  year={1983},
  volume={29 4},
  pages={
          963-9
        }
}
Although estradiol-17 beta (E2) induces premature regression of the corpus luteum (CL), its role in spontaneous luteolysis which occurs at the end of the nonfertile cycle has not been demonstrated. We compared the effects of an estrogen antagonist on E2-induced and spontaneous luteolysis by administering clomiphene (10 mg/day) to cynomolgus macaques during the luteal phase in the presence and absence of exogenous E2 (supplied by subcutaneous Silastic implants). Other animals received either… 
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TLDR
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Direct ovarian effect of clomiphene citrate in the rabbit.
TLDR
The data suggest that CC has a direct ovarian effect and that ovum degeneration associated with CC may be related to an antiestrogenic action.
The effect of luteal phase estrogen antagonism on luteinizing hormone pulsatility and luteal function in women.
TLDR
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Comparison of luteinized unruptured follicles and corpora lutea: steroid hormone production and response to luteolytic and luteotropic agents.
TLDR
It is concluded that the attenuated luteal-phase P profile following induction of LUFs is not an intrinsic deficiency in hormone production, but may arise from the smaller mass of lutenal tissue and from earlier than normal development of responsiveness to the luteolytic effects of PGF.
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