Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes.

@article{Richert2003EffectsOC,
  title={Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes.},
  author={Lysiane Richert and Christelle Lamboley and Catherine Viollon-Abadie and Peter Grass and Nicole Hartmann and St{\'e}phane Laurent and Bruno Heyd and Georges Mantion and S. Chibout and Frank Staedtler},
  journal={Toxicology and applied pharmacology},
  year={2003},
  volume={191 2},
  pages={130-46}
}
The mRNA expression profile in control and clofibric acid (CLO)-treated mouse, rat, and human hepatocytes was analyzed using species-specific oligonucleotide DNA microarrays (Affymetrix). A statistical empirical Bayes procedure was applied in order to select the significantly differentially expressed genes. Treatment with the peroxisome proliferator CLO induced up-regulation of genes involved in peroxisome proliferation and in cell proliferation as well as down-regulation of genes involved in… CONTINUE READING
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