Effects of clarithromycin and rifabutin alone and in combination on intracellular and extracellular replication of Mycobacterium avium.

@article{Mor1994EffectsOC,
  title={Effects of clarithromycin and rifabutin alone and in combination on intracellular and extracellular replication of Mycobacterium avium.},
  author={Naomi Mor and John Vanderkolk and N Mezo and Leonid B Heifets},
  journal={Antimicrobial agents and chemotherapy},
  year={1994},
  volume={38 12},
  pages={2738-42}
}
The combined effect of clarithromycin and rifabutin against Mycobacterium avium multiplying either within human monocyte-derived macrophages or extracellularly in a liquid medium was additive: both MICs and MBCs were twofold lower for the combination than they were for each drug alone. Prolonged exposure for 4 weeks of M. avium-infected macrophages to combined concentrations that were only twofold greater than the MICs resulted in a 100-fold decrease in the number of viable bacteria, while in… CONTINUE READING

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