Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses.

@article{Yaguchi2005EffectsOC,
  title={Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses.},
  author={Takahiro Yaguchi and Satoshi Yamamoto and Tetsu Nagata and Takeshi Kanno and Akito Tanaka and Tomoyuki Nishizaki},
  journal={Brain research. Molecular brain research},
  year={2005},
  volume={133 2},
  pages={
          320-4
        }
}
Linoleic acid (C18:2omega6) (10 microM) depressed ACh-evoked whole-cell membrane currents followed by potentiation of the currents in Xenopus oocytes expressing Torpedo ACh receptors. The potentiation was never obtained with linoleoylamide (10 microM), which contains CONH2 instead of COOH on linoleic acid. In the assay of protein kinase C (PKC) using a reversed phase high-performance liquid chromatography, linoleic acid activated PKC-epsilon but linoleoylamide otherwise had no effect on it. Of… CONTINUE READING
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