Effects of cinnarizine on different experimentally induced oedemas

  title={Effects of cinnarizine on different experimentally induced oedemas},
  author={G{\'a}bor Blazs{\'o} and Zsolt Razga and Mester G{\'a}bor},
  journal={Fundamental \& Clinical Pharmacology},
Abstract— Experiments with male mice (28–32 g) of the CFLP strain showed that cinnarizine in doses of 2.5, 5.0 or 10.0 mg kg−1 significantly inhibited the extent of ear oedema induced by croton oil, capsaicin or dithranol, in a dose‐dependent manner. In rats of the Wistar strain, oedema was induced in the hind paw by subplantar injection of carrageenin, and simultaneously by the application of croton oil to the inner surface of the ear. Preliminary cinnarizine treatment (5, 10 or 20 mg kg−1… 
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The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.
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    Archives internationales de pharmacodynamie et de therapie
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