Effects of cinitapride on gastric ulceration and secretion in rats

  title={Effects of cinitapride on gastric ulceration and secretion in rats},
  author={Catalina Alarc{\'o}n de la Lastra and Carmen La Casa and Mar{\'i}a Jos{\'e} Calpe Mart{\'i}n and Virginia Motilva},
  journal={Inflammation Research},
Abstract.Objective and Design: The aim of the present study was to examine the effects of cinitapride, a novel prokinetic benzamide-stimulating gastrointestinal motility agent, on gastric secretion and ulceration in rats and elucidate some possible vascular and anti-oxidant mechanisms of such protection.¶Material: Male Wistar rats.¶Treatment: Cinitapride (CNT, Lab. Almirall, S.A.) (0.25, 0.5, and 1 mg/kg) and 5-hydroxytryptamine (5-HT, Sigma Chemical Co., St. Louis, MO, USA) (10 mg/kg… Expand
11 Citations
Protective role of carnitine esters against alcohol-induced gastric lesions in rats.
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A comparative evaluation of the gastroprotective potential of hydroalcoholic extracts of an original drug Aconitum heterophyllum (HAAH) and its substitute Cyperus rotundus (HACR) in the treatment of gastric ulcer under in vivo experimental conditions confirmed that both A. heterophyLLum and C.Rotundus deliver comparable significant protection against gastric Ulcer. Expand
Efficacy and Safety of Cinitapride in the Treatment of Mild to Moderate Postprandial Distress Syndrome–predominant Functional Dyspepsia
This phase III trial has confirmed the noninferior efficacy of cinitapride over domperidone for patients with mild to moderate, postprandial distress syndrome–predominant FD, and its cardiovascular events need further evaluation. Expand
Eficacia y tolerabilidad de la cinitaprida en pacientes con reflujo gastroesofágico, dispepsia funcional y síndrome de intestino irritable
Cinitapride is effective and well tolerated in the treatment of adult patients with gastroesophageal reflux, functional dyspepsia and irritable bowel syndrome. Expand
Validated Method Development for the Quantification of Cinitapride and Pantoprazole by Spectrophotometry and RP-HPLC in Bulk and Oral Dosge form.
The present study analysis of drugs plays a major role in the development, manufacture and therapeutic use of drug. Quantitative analysis of raw materials and the final product is necessary toExpand
There was no significant difference between the two formulations of Pantoprazole 40mg+ Cinitapride 3mg Extended Release Capsules and no serious adverse events related to the study drug were reported. Expand
Therapeutic potential of serotonin 4 receptor for chronic depression and its associated comorbidity in the gut
The current review provides prospective information about the role and mechanism of 5-HT4R-based therapeutics for the treatment of depressive disorder and possible consequences for the gut via brain-gut axis interactions. Expand
4-Substituted and 1,4-Disubstituted Piperidines
This chapter describes methods of synthesis, pharmacological properties and the use of derivatives of 4-substituted and 1,4-disubstituted piperidines such as 4-piperidinols and their derivatives,Expand


Effects of cisapride on ulcer formation and gastric secretion in rats: comparison with ranitidine and omeprazol.
The results suggest that cisapride shows antiulcerogenic effects which could possibly be explained through antisecretory and cytoprotective mechanisms involving an enhancement of cuality and production of gastric mucus. Expand
Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds.
The present results demonstrate that the gastroprotective effects of CNT could be partly explained by a complex PG dependent mechanism and suggest that 5-HT dependent mechanisms through5-HT2 receptor blockade and 5- HT1 receptor activation could be also involved. Expand
Cytoprotective activity of cisapride on experimental gastric mucosal lesions induced by ethanol. Role of endogenous prostaglandins.
It is confirmed that this benzamide, in this experimental model, enhances gastric PGE2 production and its protective nature, shown macroscopic and microscopically, after 240 min of its administration, without any effect on PGs production. Expand
Inhibition of experimentally-induced gastric ulcers in the rat by a new sulfated glycopeptide
Abstract A sulfated glycopeptide (GLPS) obtained by sulfonation of a glycopeptide derived from pig duodenum was tested as an inhibitor of experimental gastric ulcers in rat. GLPS, given orally,Expand
Role of sulfhydryls in mucosal injury caused by ethanol: relation to microvascular permeability, gastric motility and cytoprotection.
The results suggest that the mucosal GSH levels do not relate directly to either development or prevention of ethanol-induced gastric injury, potentiation by NEM of the mucosa injury may be accounted for by its enhancement of the vascular permeability and inhibition of gastric motility may be associated with prevention of mucosal lesions. Expand
Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat.
In two experimental models of NSAID gastric ulceration the mucosa undergoes early contraction, vascular fibrin deposition, and necrosis prior to neutrophil infiltration, which supports a primary, neutrophIL independent, ischaemic pathogenesis for NSAID Gastric ulcersation. Expand
5-Hydroxytryptamine3-receptor blockade protects against gastric mucosal damage in rats.
Preliminary findings suggest that 5HT3-receptor blockade not only can antagonise stress- or ethanol-evoked gastric mucosal damage, but also may act through a peripheral mechanism. Expand
Ethanol-induced injury to the rat gastric mucosa. Role of neutrophils and xanthine oxidase-derived radicals.
It is concluded that ethanol is proinflammatory at concentrations that may be achieved in the gastric mucosa during acute intoxication, and the ethanol-induced, neutrophil-mediated cell injury does not appear to involve oxy radicals. Expand
The role of Gastric Mucosal Sulphydryls in the Ulcer‐protecting Effects of Cisapride
The present study was designed to examine the role of endogenous sulphydryls (SHs) in the gastro‐protection induced by cisapride (CIS) (10, 25 and 50 mg kg−1 i.p.), a potent benzamide stimulatingExpand
5‐HT2 Blockade Protects Against Gastric Ischaemia‐reperfusion Injury in Rats. Role of Oxygen Free Radicals and Lipid Peroxidation
Lipid peroxidation and active oxygen metabolites have been suggested to play an important role in the pathogenesis of acute gastric mucosal injury induced by ischaemia-reperfusion. On the-other handExpand