Effects of cinitapride on gastric ulceration and secretion in rats

  title={Effects of cinitapride on gastric ulceration and secretion in rats},
  author={Catalina Alarc{\'o}n de la Lastra and Carmen La Casa and M. D. J. Martin and Virginia Motilva},
  journal={Inflammation Research},
Abstract.Objective and Design: The aim of the present study was to examine the effects of cinitapride, a novel prokinetic benzamide-stimulating gastrointestinal motility agent, on gastric secretion and ulceration in rats and elucidate some possible vascular and anti-oxidant mechanisms of such protection.¶Material: Male Wistar rats.¶Treatment: Cinitapride (CNT, Lab. Almirall, S.A.) (0.25, 0.5, and 1 mg/kg) and 5-hydroxytryptamine (5-HT, Sigma Chemical Co., St. Louis, MO, USA) (10 mg/kg… 

Protective role of carnitine esters against alcohol-induced gastric lesions in rats.

Cerium Oxide Nanoparticles Protects Gastrointestinal Mucosa From Ethanol Induced Gastric Ulcers in In-Vivo Animal Model

Cerium oxide (CeO2) nanoparticles having size range of 160 nm were prepared by using simple and effective sol-gel process and evaluated for their ulcer protective activity in an animal model. CeO2

Efficacy and Safety of Cinitapride in the Treatment of Mild to Moderate Postprandial Distress Syndrome–predominant Functional Dyspepsia

This phase III trial has confirmed the noninferior efficacy of cinitapride over domperidone for patients with mild to moderate, postprandial distress syndrome–predominant FD, and its cardiovascular events need further evaluation.

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Cinitapride is effective and well tolerated in the treatment of adult patients with gastroesophageal reflux, functional dyspepsia and irritable bowel syndrome.

Validated Method Development for the Quantification of Cinitapride and Pantoprazole by Spectrophotometry and RP-HPLC in Bulk and Oral Dosge form.

The developed UV – Visible and RP-HPLC methods were found to be simple, precise, accurate and rapid methods for the analysis of Cinitapride and Pantoprazole in its pure form and in its pharmaceutical dosage formulation.


There was no significant difference between the two formulations of Pantoprazole 40mg+ Cinitapride 3mg Extended Release Capsules and no serious adverse events related to the study drug were reported.



Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds.

The present results demonstrate that the gastroprotective effects of CNT could be partly explained by a complex PG dependent mechanism and suggest that 5-HT dependent mechanisms through5-HT2 receptor blockade and 5- HT1 receptor activation could be also involved.

Role of sulfhydryls in mucosal injury caused by ethanol: relation to microvascular permeability, gastric motility and cytoprotection.

The results suggest that the mucosal GSH levels do not relate directly to either development or prevention of ethanol-induced gastric injury, potentiation by NEM of the mucosa injury may be accounted for by its enhancement of the vascular permeability and inhibition of gastric motility may be associated with prevention of mucosal lesions.

Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat.

In two experimental models of NSAID gastric ulceration the mucosa undergoes early contraction, vascular fibrin deposition, and necrosis prior to neutrophil infiltration, which supports a primary, neutrophIL independent, ischaemic pathogenesis for NSAID Gastric ulcersation.

5-Hydroxytryptamine3-receptor blockade protects against gastric mucosal damage in rats.

Preliminary findings suggest that 5HT3-receptor blockade not only can antagonise stress- or ethanol-evoked gastric mucosal damage, but also may act through a peripheral mechanism.

The role of Gastric Mucosal Sulphydryls in the Ulcer‐protecting Effects of Cisapride

The present study was designed to examine the role of endogenous sulphydryls (SHs) in the gastro‐protection induced by cisapride (CIS) (10, 25 and 50 mg kg−1 i.p.), a potent benzamide stimulating

5‐HT2 Blockade Protects Against Gastric Ischaemia‐reperfusion Injury in Rats. Role of Oxygen Free Radicals and Lipid Peroxidation

The results suggest that selective blockade of 5-HT2 receptors by ketanserin may be effective on ischaemia-reperfusion gastric injury.