Effects of cilnidipine on serum uric acid level and urinary nitrogen monoxide excretion in patients with hypertension.

Abstract

The effects of cilnidipine on the serum uric acid level and urinary NO excretion in hypertensive patients were investigated. Blood and urine samples of 16 hypertensive outpatients were collected before and 2 months after cilnidipine therapy (10 mg). The serum uric acid level decreased significantly after cilnidipine treatment, while the uric acid-creatinine clearance ratio was unaffected. The cilnidipine medication produced a significant increase in urinary NO excretion, although amlodipine did not change it significantly. Therefore, cilnidipine has a profound antihypertensive effect and may reduce the serum uric acid level and increase NO production in the kidney.

DOI: 10.3109/10641963.2012.666600

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@article{Hamada2012EffectsOC, title={Effects of cilnidipine on serum uric acid level and urinary nitrogen monoxide excretion in patients with hypertension.}, author={Toshihiro Hamada and Kensaku Yamada and Einosuke Mizuta and Arisa Watanabe and Tomohiro Osaki and Katsunori Ishida and Akira Hasegawa and Shinji Sakata and Mutsuo Mishima and Kazuhide Ogino and Yoshihito Nosaka and Satoshi Miyazaki and Akira Ohtahara and Haruaki Ninomiya and Masahiko Kato and Akio Yoshida and Shin-ichi Taniguchi and Kazuhiro Yamamoto and Ichiro Hisatome}, journal={Clinical and experimental hypertension}, year={2012}, volume={34 7}, pages={470-3} }