Effects of cigarette smoke on the human airway epithelial cell transcriptome.

@article{Spira2004EffectsOC,
  title={Effects of cigarette smoke on the human airway epithelial cell transcriptome.},
  author={Avrum Spira and Jennifer Beane and Vishal Shah and Gang Liu and Frank Schembri and Xuemei Yang and John F. Palma and Jerome S. Brody},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 27},
  pages={10143-8}
}
Cigarette smoke is the major cause of lung cancer, the leading cause of cancer death, and of chronic obstructive pulmonary disease, the fourth leading cause of death in the United States. Using high-density gene expression arrays, we describe genes that are normally expressed in a subset of human airway epithelial cells obtained at bronchoscopy (the airway transcriptome), define how cigarette smoking alters the transcriptome, and detail the effects of variables, such as cumulative exposure, age… CONTINUE READING
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