Effects of chronically elevated intake of different concentrations of saccharin on morphine tolerance in genetically selected rats

@article{Cohen1984EffectsOC,
  title={Effects of chronically elevated intake of different concentrations of saccharin on morphine tolerance in genetically selected rats},
  author={Edna Cohen and Israel Lieblich and Felix Bergmann},
  journal={Physiology & Behavior},
  year={1984},
  volume={32},
  pages={1041-1043}
}
Sixty-four LC2-Hi and LC2-Lo female rats were chronically supplied with either water or a solution of 1, 3 or 30 mM of sodium-saccharin. Pain sensitivity, as well as its reduction by a 2.5 mg/kg morphine injection, were measured in a hot-plate test. High saccharin consuming LC2-Hi rats did not exhibit significant morphine-induced analgesia (MIA) compared to baseline, after 38 days of drinking of saccharin, irrespective of concentration. MIA of those rats were maintained on water was significant… CONTINUE READING