Effects of chronic zimelidine and ethanol on psychomotor performance.

  title={Effects of chronic zimelidine and ethanol on psychomotor performance.},
  author={M. Linnoila and K. Dubyoski and R. Rawlings and M. Rudorfer and M. Eckardt},
  journal={Journal of clinical psychopharmacology},
  volume={5 3},
Twelve healthy men between 22 and 27 years of age participated in an experiment on interactions between zimelidine and ethanol. Zimelidine, 200 mg/24 hours, was administered for 10 days and ethanol, 0.5 and 1.0 g/kg of body weight, or placebo drinks were administered either with placebo capsules or on the last 3 days of zimelidine treatment. A battery of tests measuring skilled performance was used. The higher dose of ethanol increased plasma zimelidine and norzimelidine concentrations. Ethanol… Expand