Effects of chronic zimelidine and ethanol on psychomotor performance.

@article{Linnoila1985EffectsOC,
  title={Effects of chronic zimelidine and ethanol on psychomotor performance.},
  author={M. Linnoila and K. Dubyoski and R. Rawlings and M. Rudorfer and M. Eckardt},
  journal={Journal of clinical psychopharmacology},
  year={1985},
  volume={5 3},
  pages={
          148-53
        }
}
Twelve healthy men between 22 and 27 years of age participated in an experiment on interactions between zimelidine and ethanol. Zimelidine, 200 mg/24 hours, was administered for 10 days and ethanol, 0.5 and 1.0 g/kg of body weight, or placebo drinks were administered either with placebo capsules or on the last 3 days of zimelidine treatment. A battery of tests measuring skilled performance was used. The higher dose of ethanol increased plasma zimelidine and norzimelidine concentrations. Ethanol… Expand
The feasibility of effective psychopharmacological treatments for alcoholism.
TLDR
Since the known drugs that appear beneficial against human alcohol abuse also suppress voluntary alcohol selection by experimental animals, it seems likely that studies with animals could be used for screening other potentially effective drugs. Expand
The effects of citalopram in single and repeated doses and with alcohol on physiological and psychological measures in healthy subjects
TLDR
It is concluded that in clinical use citalopram should have little or no effect on cognitive and psychomotor performance, produce minimal sedation but some nausea, loss of appetite and insomnia. Expand
Amitriptyline, clovoxamine and cognitive function: a placebo-controlled comparison in depressed outpatients
TLDR
Evidence is added that antidepressant drugs with high anticholinergic activity can impair memory, despite alleviation of depression, by testing the alternative hypothesis that amitriptyline would exacerbate depressed patients' cognitive disturbances. Expand
Pharmacological treatment of alcohol intoxication, withdrawal and dependence: a critical review.
This review critically examines the literature of the past 10 years relating to the use of drugs in treating alcohol intoxication, withdrawal and dependence. Emphasis is given to those studies thatExpand
Antidepressants and driving.
Although some impairment of skills due to antidepressants has been observed clinically, the impact of antidepressants on traffic safety is at present unknown.