Effects of chronic volume expansion and enalapril on chronic cyclosporine nephropathy.

@article{Gillum1990EffectsOC,
  title={Effects of chronic volume expansion and enalapril on chronic cyclosporine nephropathy.},
  author={D M Gillum and Loanne Truong},
  journal={The American journal of physiology},
  year={1990},
  volume={258 4 Pt 2},
  pages={F934-9}
}
Prolonged treatment with cyclosporine (CS) results in an irreversible renal lesion consisting of interstitial fibrosis and tubular atrophy, as well as prominent hyperplasia of the juxtaglomerular apparatus (JGA). Ischemia to the tubulointerstitial compartment caused by intense CS-mediated renal vasoconstriction may contribute significantly to the development of this lesion. To explore the potential role of volume contraction and activation of the renin-angiotensin system (RAS) in the genesis of… CONTINUE READING