Effects of chronic vagal nerve stimulation in the treatment of β-AMYLOID induced neuropsychiatric symptoms.

  title={Effects of chronic vagal nerve stimulation in the treatment of $\beta$-AMYLOID induced neuropsychiatric symptoms.},
  author={Metin Yesiltepe and Bariscan Cimen and Yildirim Sara},
  journal={European journal of pharmacology},



Vagus nerve stimulation…25 years later! What do we know about the effects on cognition?

Vagus nerve stimulation in patients with Alzheimer's disease: Additional follow-up results of a pilot study through 1 year.

The results of this study support long-term tolerability of VNS among patients with AD and warrant further investigation.

The Acute Effects of Amyloid-Beta1–42 on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus

It is shown that acute injection of Aβ1–42 is sufficient to induce cognitive deficits 3 days post-injection and implies a much more complex circuit mechanism associated with glutamatergic dysfunction than simply glutamate-mediated excitotoxic neuronal death.

Diagnosing and Treating Depression in Patients with Alzheimer’s Disease

Clinical consensus and research appear to support selective serotonin reuptake inhibitors as a first choice for the pharmacological treatment of depression in patients with dementia, however, initial support for these therapies remains variable, and further investigation is needed.

Vagus nerve stimulation improves working memory performance

It is found that vagus nerve stimulation improved working memory performance as seen in reduced errors on a subtask that relied on working memory, and immediate effects on emotional reactivity evidenced in behavior and brain physiology are shown.

Two-Year Outcome of Vagus Nerve Stimulation in Treatment-Resistant Depression

The results of this 2-year open-label trial suggest a clinical response and a comparatively benign adverse effect profile among patients with treatment-resistant depression.

Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder

An overview of NMR-based measurements of glutamate and GABA homeostasis, neurometabolic activity, and neurotransmitter cycling in MDD is provided and the impact of recent advancements in treatment strategies against a depressive disorder that target glutamate and neurons in the brain is highlighted.

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

The goal of this review is to discuss how behavioral tests in mice relate to the pathological and neuropsychological features seen in human Alzheimer's disease (AD), and present a comprehensive