Effects of chronic triclosan exposure upon the antimicrobial susceptibility of 40 ex-situ environmental and human isolates.

@article{Ledder2006EffectsOC,
  title={Effects of chronic triclosan exposure upon the antimicrobial susceptibility of 40 ex-situ environmental and human isolates.},
  author={Ruth G Ledder and Peter Gilbert and Caroline Willis and Andrew J McBain},
  journal={Journal of applied microbiology},
  year={2006},
  volume={100 5},
  pages={1132-40}
}
BACKGROUND Triclosan (TCS) exposure of Escherichia coli selects for tolerant clones, mutated in their enoyl-acyl carrier protein reductase (FabI). It has been inferred that this phenomenon is widespread amongst bacterial genera and might be associated with resistance to third party agents. METHODS Ex-situ, low passage isolates of enteric, human axilla, human oral origin and bacteria isolated from a domestic drain, together with selected type cultures were exposed to escalating concentrations… CONTINUE READING
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