Effects of chronic treatment with citalopram on cannabinoid and opioid receptor-mediated G-protein coupling in discrete rat brain regions

@article{Hesketh2007EffectsOC,
  title={Effects of chronic treatment with citalopram on cannabinoid and opioid receptor-mediated G-protein coupling in discrete rat brain regions},
  author={S. A. Hesketh and A. K. Brennan and D. Jessop and D. Finn},
  journal={Psychopharmacology},
  year={2007},
  volume={198},
  pages={29-36}
}
RationaleThere is growing interest in investigating the mechanisms of action of selective serotonin reuptake inhibitors (SSRIs), beyond their association with the serotonergic system, due to their wide therapeutic potential for disorders including depression, pain and addiction.ObjectiveThe aim of this study was to investigate whether chronic treatment with the SSRI, citalopram, alters the functional coupling of Gi/o-associated cannabinoid type 1 (CB1) and μ-opioid receptors in selected areas… Expand
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