Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart.

@article{Lazarous1995EffectsOC,
  title={Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart.},
  author={Daisy F. Lazarous and Mickey Scheinowitz and Matie Shou and Ernest Hodge and S Rajanayagam and Sally Hunsberger and W. Gerald Robison and Jonathan A. Stiber and Rosaly Correa and Stephen E. Epstein},
  journal={Circulation},
  year={1995},
  volume={91 1},
  pages={145-53}
}
BACKGROUND Recently we reported that intracoronary administration of basic fibroblast growth factor (bFGF), a potent angiogenic peptide, increases collateral blood flow in dogs subjected to progressive left circumflex coronary artery (LCx) occlusion. The aim of the present study was to examine the effect of systemically administered bFGF on collateral blood flow and to assess its pharmacokinetics and potential side effects. METHODS AND RESULTS Forty-seven dogs were subjected to progressive… CONTINUE READING