Effects of chronic sildenafil use on pulmonary hemodynamics and clinical outcomes in heart transplantation.

@article{Pons2012EffectsOC,
  title={Effects of chronic sildenafil use on pulmonary hemodynamics and clinical outcomes in heart transplantation.},
  author={Jaume Pons and M. F. Leblanc and Mathieu Bernier and Bernard Cantin and Christine Bourgault and Sebastien J Bergeron and Guy Proulx and Joelle Morin and Chiara Nalli and Kim M O'Connor and Nathalie Chateauvert and Mario S{\'e}n{\'e}chal},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2012},
  volume={31 12},
  pages={1281-7}
}
BACKGROUND Elevated pulmonary vascular resistance (PVR) in heart transplant (HT) candidates is associated with poor survival after HT. This study assessed the effect of peri-operative sildenafil administration on pulmonary hemodynamics and clinical outcomes in patients with advanced heart failure who were considered high-risk for HT because of elevated PVR and transpulmonary gradient (TPG). METHODS The study included 119 consecutive patients who underwent HT between 2004 and 2011. Fifteen… CONTINUE READING